Through this Funding Opportunity Announcement (FOA), the National Institute of Mental Health (NIMH) seeks Resource-Related Cooperative Agreement (U24) applications to continue, enhance, and enrich research resources in the NIMH Human Genetics Initiative for free and open sharing with the scientific community. The long-term objective of data sharing and research resource enrichment under this FOA is to accelerate gene discovery in mental disorders. It is expected that the Center will be comprised of a team of investigators with expertise in molecular biology, cell culture, computer and information sciences, statistical genetics and psychiatric genetics. It is also expected that this effort will involve activities at multiple institutions that are strategically and functionally coordinated such that the Center will function as a single, national resource.
Only one application per institution (normally identified by having a unique DUNS number or NIH IPF number) is allowed.
A critical feature of the Center will be the banking of primary cultures of source cells for the derivation of induced pluripotent stem cells (iPSCs) and the banking of established iPSCs by investigators. Furthermore, the development and maintenance of a genomic cyberinfrastructure is required. Such an infrastructure will represent the coordinated aggregate of software, hardware and other technologies, as well as the necessary staff expertise required to support current and future discoveries in the genetics of mental disorders. This cyberinfrastructure will integrate relevant and often disparate genetic and genomic resources to provide a useful, usable, and enabling framework for human genetic research and gene discovery in mental disorders that will be characterized by broad access.
NIMH intends to commit approximately $9,000,000 in FY 2013 to fund one new cooperative agreement in response to this FOA. An application may request up to $9,000,000 total cost per year. The total project period may not exceed 5 years.
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