This FOA solicits applications to participate in the Autoimmunity Centers of Excellence (ACE) program, a cooperative network intended to improve the understanding and treatment of autoimmune diseases (www.autoimmunitycenters.org). The ACE program was founded on the premise that collaboration among basic and clinical scientists can accelerate both fundamental and applied research. For this reissuanc, the formerly integrated Centers are divided into Basic and Clinical research programs. This FOA solicits applications for the Clinical research program; a companion FOA solicits applications for the Basic research program. The members of the Basic and Clinical ACE will work together to design and conduct studies of mechanisms of action of immune-modulating agents tested in clinical trials.
Only one application per institution (normally identified by having a unique DUNS number or NIH IPF number) is allowed. The same institution may also apply to the companion FOA. A single PD/PI, and PDs/PIs on a multiple-PD/PI application, may NOT also serve as PDs/PIs on an application to the companion FOA.
An individual may serve as PD/PI on an application to either this ACE Clinical program FOA or the companion Basic program FOA but not both. PD(s)/PI(s) should commit at least 2.4 person months effort (total for multiple PDs/PIs). A PD/PI may lead no more than one of the proposed Projects. The PD/PI (or one of the PDs/PIs if multiple PDs/PIs) should also lead the Administrative Core.
Cooperative agreement. NIAID anticipates awarding up to $1.2 million in direct costs in FY 2014 to fund up to 4 new or renewal grants within the ACE Clinical program. Additional funds will be awarded to support the Clinical Project Fund and an Opportunity Fund.
Applicants to the ACE Clinical program can request up to $700,000 (direct costs) each per year for the Primary and Alternate Clinical Projects. It is anticipated that this FOA will fund successful applicants up to $50,000 per year direct costs for planning further development of successful Clinical Trial Projects. It is anticipated that Funds for implementing the full Clinical Trial Projects will be provided by the ACE Funds Management Core.
In addition, applicants can request up to $50,000 per year in direct costs for the Administrative Core. Applications containing an optional Collaborative Project may request up to $250,000 per year in additional direct costs. Support for the optional ACE Funds Management Core is limited to $250,000 per year in direct costs.
The maximum project period is five years.
Internal Selection Procedure
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