National Institutes of Health

NIH: Botanical Dietary Supplement Research Centers (BDSRC) (P50)

Program Summary

This Funding Opportunity Announcement (FOA) invites applications to support research centers to develop and apply cutting-edge, transdisciplinary approaches to the study of botanicals with relevance to human health, that are found as ingredients in dietary supplements. These centers are expected to synergistically integrate a range of relevant disciplines (e.g., phytochemistry, botany, and expertise utilizing models ranging from in silico through in vitro to in vivo) to conduct innovative research to elucidate the interactions between complex botanical products and human biology. The long-term goal of this program is to support development of the preclinical data required for optimal design of rigorous, definitive clinical research on complex botanical products. Given the extensive resources required for clinical research it is critical that clinical trials of botanicals be supported by solid and extensive relevant preclinical data, especially with respect to mechanisms of action, optimal formulations and dosing, for example. Therefore the focus of these Centers will be on basic and preclinical research. The focus of this FOA is on research on the mechanisms of action of botanicals traditionally used for health maintenance, or on botanicals with strong evidence of promise for improving objective, quantitative measures of organism resilience. Use of relevantvertebrate and invertebrate models is strongly encouraged. A strictly limited number of human subjects research aims, designed to interrogate, e.g., in vivo mechanism(s) of action, safety, pharmacokinetics, or bases of individual differences in metabolism or response, may be included.


Only one application per institution is allowed.

Award Information

ODS and NCCAM intend to commit an estimated total of not more than $10 million per year in total costs to support up to five awards.  Application budgets may not exceed $1.25 million in direct costs but need to reflect the actual needs of the proposed project.  The scope of the proposed project should determine the project period. The maximum project period is 5 years. 

Internal Selection Procedure
The UI Office of the Vice President for Research and Economic Development and the Carver College of Medicine have established an internal review procedure to select the UI nominee. Applications will be reviewed according to the sponsor's selection criteria. Consideration will also be given to UI institutional strengths and strategic directions. Potential applicants must submit, using the preselection link below, the following information:
  1. A two page CV; and
  2. A description of the proposed project. It should have the following elements:
The above materials must be submitted no later than 5:00 p.m. on Friday, March 28, 2014. The selected nominee will be asked to complete the full application package in accordance with the sponsor's deadline of Friday, June 6, 2014.

Proposal Due to OVPRED03/28/2014 Not open for submission deadline passed
Date Due to DSP or UIF05/31/2014
Date Due to Sponsor06/06/2014
Required LOI Due DateN/A
Non-Required LOI Due Date04/06/2014
Sponsor URL:

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