Technology Information

Metal Chelators that Prevent Pseudomonas Biofilms in Medical & Other Applications

Lactoferrin & conalbumin, proteinaceous metal chelators, have been shown to prevent and break down Pseudomas aeruginosa biofilms by sequestering free iron.
UIRF Case #:02042


Relevant PublicationsLevel of Development
Technology DescriptionInventor Web Site Link
Patent LinksContact Information
Other Information 

Relevant Publications

Singh PK, Parsek MR, Greenberg EP, Welsh MJ. A component of innate immunity prevents bacterial biofilm development. Nature. 2002 May 30;417(6888):552-5.
Link

Level of Development

General: Experimental Proof of Concept

Technology Description

Researchers at the University of Iowa have identified a pair of proteinaceous metal chelators, lactoferrin and conalbumin, that are able to prevent and dissipate Pseudomonas aeruginosa biofilms. These compositions are able to bind free iron, which is required for biofilm formation by the pathogen. With this co-factor removed, the protective biofilm disperses and the constituent bacterial cells lose the protective aspects of the biofilms. For example, the resistance to commonly used antibiotics, such as tobramycin, ciprofloxin, aminoglycosides, etc. which is conferred by the biofilm is lost when these drugs are co-administered with the proteinaceous metal chelators. This is illustrated in the colony formation assay experiment below in which tobramycin and hydrogen peroxide are used to treat a P. aeruginosa biofilm alone and in conjunction with conalbumin. These compositions are also effective outside of medicine where biofilms are also an issue, such as water treatment and other industrial applications.

Patent Link(s)

US7446089    US8343911    US20130210708    EP1499341A2    

Contact Information

Zev Sunleaf
zev-sunleaf@uiowa.edu
319-335-4155

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