Technology Information

A Thiazolidinethione Indene-based Chiral Auxiliary for the Creation of Stereoselective Products

This chiral auxiliary can be used for both propionate and acetate aldol additions.
UIRF Case #:08031

Relevant PublicationsLevel of Development
Technology DescriptionInventor Web Site Link
Patent LinksContact Information
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Relevant Publications

Osorio-Lozada A, Olivo HF. Indene-based thiazolidinethione chiral auxiliary for propionate and acetate aldol additions. Org Lett. 2008 Feb 21;10(4):617-20.

Level of Development

General: Experimental Proof of Concept

Technology Description

Researchers at the University of Iowa have developed a new chiral auxiliary which can be used in both propionate and acetate aldol stereoselective reactions. This technology utilizes a thiazolidinethione indene-based chiral auxiliary, which can be synthesized from commercially-available starting materials. Studies have demonstrated that the rigidity and nature of this chiral auxiliary promise to deliver high diastereoselectivities in aldol reactions and crystalline products.

Inventor Web Site Link(s)

Patent Link(s)


Contact Information

Sean Kim