Technology Information

Peptide Modifications for Targeting AAV to the Brain

New short peptide sequences have been identified which are able to target AAV preferentially to the wild type and diseased brain.
UIRF Case #:08006


Relevant PublicationsLevel of Development
Technology DescriptionInventor Web Site Link
Patent LinksContact Information
Other Information 

Relevant Publications

Chen YH, Chang M, Davidson BL. Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy. Nat Med. 2009 Oct; 15(10): 1215-8.
Link

Level of Development

General: Working Prototype

Technology Description

Researchers at the University of Iowa have discovered a series of peptide sequences that demonstrate selective tropism for endothelial cells of the brain vasculature when expressed on the surface of AAV. Furthermore, studies have shown that unique groups of peptide sequences target AAV vectors to wild type brain versus brains afflicted by lysosomal storage diseases. Wild type mouse brain cells were targeted by sequences within the family of PXXPS, SPXXP, TLH & QSXY; the brain cells in lysosomal storage disease mouse models lacking functional beta-glucuronidase were targeted by sequences within the family of LXSS, PFXG & SIXA; and the brain cells of lysosomal storage disease mouse models lacking tripeptidyl peptidase I (TPP-1) were targeted by the peptide GMNAFRA. Studies also showed that delivery of the missing functional gene through the utilization of these targeting peptides on AAV vectors resulted in the return of functional protein to the effected region and therapeutic benefit to the animal model.

Inventor Web Site Link(s)

http://genetherapy.anatomy.uiowa.edu:8080/genetherapy/introduction.jsp?first=Beverly&last=Davidson&middle=L
http://www.healthcare.uiowa.edu/labs/davidson/

Patent Link(s)

US8299215    US8691948    AT8781733.4    BE8781733.4    BG8781733.4    CA2693712    CY8781733.4    CZ8781733.4    DE8781733.4    

Contact Information

Catherine Koh
catherine-koh@uiowa.edu
319-335-4659

6 Gilmore Hall, 112 N. Capitol Street, Iowa City, IA 52242     phone: 319-335-4546 fax: 319-335-4486 © University of Iowa 2007. All rights reserved.