Technology Information

New siRNA Sequences & Methods for Treating Huntington Disease

The use of specific sequences and a structural hairpin have been demonstrated to modulate expression of the Huntington Disease protein in vitro & in vivo.
UIRF Case #:07078


Relevant PublicationsLevel of Development
Technology DescriptionInventor Web Site Link
Patent LinksContact Information
Other Information 

Relevant Publications

Level of Development

General: in vitro

Technology Description

Researchers at the University of Iowa have identified new sequences for their siRNA-based method to potentially treat Huntington Disease. The invention consists of four new short sequences specific for unique regions of the Huntingtin mRNA. These sequences have been shown to knock down expression of their target genes at the mRNA and protein levels both in vitro and in vivo. Furthermore, studies in mouse brain have clearly shown that treatment results in an elimination of the accumulation of Huntington Disease protein inclusions in brain sections. Researchers have also demonstrated that the inclusion of a structural hairpin and overhang regions on the siRNA construct clearly increase their inhibitory activity.

Inventor Web Site Link(s)

http://genetherapy.anatomy.uiowa.edu:8080/genetherapy/introduction.jsp?first=Beverly&last=Davidson&middle=L
http://www.healthcare.uiowa.edu/labs/davidson/

Patent Link(s)

US8487088    

Contact Information

Catherine Koh
catherine-koh@uiowa.edu
319-335-4659

6 Gilmore Hall, 112 N. Capitol Street, Iowa City, IA 52242     phone: 319-335-4546 fax: 319-335-4486 © University of Iowa 2007. All rights reserved.