Technology Information

RNA Interference Mediated Inactivation of Hepatitis B

A specific molecular mechanism has been developed that molecularly targets hepatitis B virus and prevent its spread.
UIRF Case #:07061


Relevant PublicationsLevel of Development
Technology DescriptionInventor Web Site Link
Patent LinksContact Information
Other Information 

Relevant Publications

McCaffrey AP, Nakai H, Pandey K, Huang Z, Salazar FH, Xu H, Wieland SF, Marion PL, Kay MA. Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol. 2003 Jun;21(6):639-44.
Link

Keck K, Volper EM, Spengler RM, Long DD, Chan CY, Ding Y, McCaffrey AP. Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiency. Mol Ther. 2009 Mar;17(3):538-47.
Link

McCaffrey AP. RNA interference inhibitors of hepatitis B virus. Ann N Y Acad Sci. 2009 Sep;1175:15-23.
Link

Level of Development

General: Experimental Proof of Concept

Technology Description

Researchers at the University of Iowa have created a molecular method for the inhibition of hepatitis B virus replication. This method could be easily modified to target other viral diseases of interest as well. It utilizes RNA interference specific for key sequences in the viral genome. When added to infected cells, the RNA sequences specifically bind to and initiate the destruction of viral transcripts via endogenous cellular machinery.

Patent Link(s)

US8232257    US20120297495    

Contact Information

Kellen Sensor
kellen-sensor@uiowa.edu
319-335-4073

6 Gilmore Hall, 112 N. Capitol Street, Iowa City, IA 52242     phone: 319-335-4546 fax: 319-335-4486 © University of Iowa 2007. All rights reserved.