RNA Interference Mediated Inactivation of Hepatitis B
A specific molecular mechanism has been developed that molecularly targets hepatitis B virus and prevent its spread.
UIRF Case #:07061
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|Technology Description||Inventor Web Site Link|
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McCaffrey AP, Nakai H, Pandey K, Huang Z, Salazar FH, Xu H, Wieland SF, Marion PL, Kay MA. Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol. 2003 Jun;21(6):639-44.
Keck K, Volper EM, Spengler RM, Long DD, Chan CY, Ding Y, McCaffrey AP. Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiency. Mol Ther. 2009 Mar;17(3):538-47.
McCaffrey AP. RNA interference inhibitors of hepatitis B virus. Ann N Y Acad Sci. 2009 Sep;1175:15-23.
Level of Development
General: Experimental Proof of Concept
Researchers at the University of Iowa have created a molecular method for the inhibition of hepatitis B virus replication. This method could be easily modified to target other viral diseases of interest as well. It utilizes RNA interference specific for key sequences in the viral genome. When added to infected cells, the RNA sequences specifically bind to and initiate the destruction of viral transcripts via endogenous cellular machinery.